Copper(II)-mediated dehydrogenative cross-coupling of heteroarenes.
نویسندگان
چکیده
Cu(OAc)(2)-mediated dehydrogenative cross-coupling between two heteroarenes has been realized in the absence of any other additive. A mechanism involving a formal Cu(II) to Cu(0) route by convergent disproportionation of the copper mediator is proposed and has been evidenced by copper mirror formation during the reaction. This synthetic protocol provides a concise and "green" access to unsymmetrical biheteroarenes bearing structural motifs of substantial utility in organic synthesis.
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ورودعنوان ژورنال:
- Organic letters
دوره 14 15 شماره
صفحات -
تاریخ انتشار 2012